Relative Resistance of Cdk5-phosphorylated CRMP2 to Dephosphorylation

Phosphorylation of CRMP2 by Cdk5 Regulates Dendritic Spine Development of Cortical Neuron in the Mouse Hippocampus.

Proper density and morphology of dendritic spines are important for higher brain functions such as learning and memory. However, our knowledge about molecular mechanisms that regulate thedevelopment and maintenance of dendritic spines is limited. We recently reported that cyclin-dependent kinase 5 (Cdk5) is required for the development and maintenance of dendritic spines of cortical neurons in ...

Introduction of new indices to identify relative drought tolerance and resistance in wheat genotypes

Differential regulation of collapsin response mediator protein 2 (CRMP2) phosphorylation by GSK3ß and CDK5 following traumatic brain injury

Aberrant ion channel function has been heralded as a main underlying mechanism driving epilepsy and its symptoms. However, it has become increasingly clear that treatment strategies targeting voltage-gated sodium or calcium channels merely mask the symptoms of epilepsy without providing disease-modifying benefits. Ion channel function is likely only one important cog in a highly complex machine...

Relative levels of resistance to bacterial canker in Iranian apricot hybrids

Mohammadi R, Keshavarzi M, Hassanzadeh N, Dejampour J, Farhadnejad A (2021) Relative resistance levels to bacterial canker in Iranian apricot hybrids. Plant Pathology Science 10(2):15-29.           Doi: 10.2982/PPS.10.2.15.   Introduction: Bacterial canker caused by Pseudomonas syringae is one of the most damaging diseases in apricots. This experiment was conducted to evaluate relative resist...

Phosphorylation of CRMP2 (collapsin response mediator protein 2) is involved in proper dendritic field organization.

Collapsin response mediator proteins (CRMPs) are intracellular proteins that mediate signals for several extracellular molecules, such as Semaphorin3A and neurotrophins. The phosphorylation of CRMP1 and CRMP2 by Cdk5 at Ser522 is involved in axonal guidance and spine development. Here, we found that the Ser522-phosphorylated CRMP1 and/or CRMP2 are enriched in the dendrites of cultured cortical ...